DJ-1, a Target Protein for an Endocrine Disrupter, Participates in the Fertilization in Mice
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概要
- 論文の詳細を見る
DJ-1 was first identified as an activated ras-dependent oncogene product and was later also found to be an infertility-related protein affected by sperm toxicants such as ornidazole (OR) and epichlorohydrin. These findings suggest that DJ-1 has functions in both somatic cells and sperm. In this study, to determine the relationship between DJ-1 and an endocrine disrupter and to determine the functions of DJ-1 in sperm, in vitro fertilization experiments were carried out using eggs and sperm extracted from mice that had or had not been treated with OR. We found that the amount of DJ-1 in sperm and the efficiency of fertilization decreased with the increasing dose of OR to which the mice were exposed. The addition of an anti-mouse DJ-1 serum to sperm solution before the in vitro fertilization reaction with eggs resulted in a decrease in the efficiency of fertilization to about onethird of that when pre-immune serum was added to sperm solution, indicating that DJ-1 participates in the fertilization.
- 公益社団法人日本薬学会の論文
- 2002-07-01
著者
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ARIGA Hiroyoshi
Graduate School of Pharmaceutical Sciences, Hokkaido University
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Matsumoto Ken-ichi
Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.
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Okada M
Graduate School Of Pharmaceutical Sciences Hokkaido University
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OKADA Masahiko
Graduate School of Pharmaceutical Sciences, Hokkaido University
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MATSUMOTO Ken-ichi
Graduate School of Pharmaceutical Sciences, Hokkaido University
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NIKI Takeshi
CREST Japan Science and Technology Corporation
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TAIRA Takahiro
Graduate School of Pharmaceutical Sciences, Hokkaido University
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IGUCHI-ARIGA Sanae
College of Medical Technology, Hokkaido University
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Takenawa Tadaomi
Division Of Biochemistry Institute Of Medical Science University Of Tokyo
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Iguchi-ariga Sanae
College Of Medical Technology Hokkaido University
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Taira Takahiro
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
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Ariga Hiroyoshi
Graduate School Of Pharmaceutical Sciences Hokkaido University
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MATSUMOTO Ken-ichi
Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Okada Masahiko
Graduate School Of Pharmaceutical Sciences Hokkaido University
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Matsumoto Ken-ichi
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
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Matsumoto Ken-ichi
Graduate School Of Information Science Nara Institute Of Science And Technology
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Taira T
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
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Ariga H
Graduate School Of Pharmaceutical Sciences Hokkaido University
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