Strong Antihyperglycemic Effects of Water-Soluble Fraction of Brazilian Propolis and Its Bioactive Constituent, 3,4,5-Tri-O-caffeoylquinic Acid(Medicinal Chemistry)
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概要
- 論文の詳細を見る
To clarify the suppression of postprandial blood glucose rise via α-glucosidase (AGH) inhibitory action by natural compounds, propolis was examined in this study. A single oral administration of propolis extract (50% methanol fraction on XAD-2 column chromatography) in Sprague-Dawley rats demonstrated a potent antihyperglycemic effect with the significant AUC_<0-120min> reduction of 38% at a dose of 20 mg/kg compared to that of controls. Among the active compounds isolated from the fraction, 3,4,5-tri-caffeoylquinic acid was found to be a prominent candidate that exerts the effect and shows a strong maltase-specific inhibition with an IC_<50> value of 24 μM. In addition, the noncompetitive inhibition power apparently increased with the number of caffeoyl groups bound to quinic acid.
- 公益社団法人日本薬学会の論文
- 2004-11-01
著者
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山田 治民
(株) ディ・ディ・エス研究所
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Doi Shima
Yamada Apiculture Center, Inc.
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YAMADA Hideo
Yamada Apiculture Center, Inc.
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Doi S
Yamada Apiculture Center Inc.
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Doi Shima
九州大学 薬学研究院
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MATSUMOTO Kiyoshi
Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu Universi
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Doi Shima
Yamada Apiculture Center Inc.
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Yamada H
Yamada Apiculture Center Inc.
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Matsumoto Ken-ichi
Dep. Of Biosignaling And Radioisotope Experiment Center For Integrated Res. In Sci. Shimane Univ.
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Matsumoto Ken-ichiro
Departments Of Physical Chemistry Showa Pharmaceutical University
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Matsui T
Kyushu Univ. Fukuoka Jpn
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Matsui Toshiro
Fac. Of Agriculture Graduate School Of Kyushu Univ.
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Matsui Toshiro
Department Of Electrical And Electronic Engineering Tokyo Institute Of Technology
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Matsui Toshiro
Department Of Applied Chemistry Faculty Of Engineering Doshisha University
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Fujise Tomoko
Nakamura Gakuen Univ. Fukuoka Jpn
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Matsumoto K
Graduate School Of Bioresource And Bioenvironmental Sciences Kyushu Univ.
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FUJISE Tomoko
Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, F
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EBUCHI Sumi
Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, F
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ABESUNDARA Kanthi
Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, F
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Yamada H
School Of Science And Technology Kwansei Gakuin University
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Matsumoto K
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Fujise Tomoko
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Ebuchi Sumi
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Toshiro Matsui
Faculty Of Agriculture Graduate School Kyushu University
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Yamada Harutami
Drug Delivery System Institute Ltd.:(present Address)tanabe Seiyaku Co. Ltd.
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MATSUMOTO Ken-ichi
Denartment of Molecular Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Abesundara K
Department Of Bioscience And Biotechnology Division Of Bioresource And Bioenvironmental Sciences Fac
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Matsumoto Kiyoshi
Department Of Applied Chemistry Faculty Of Engineering Kanagawa University
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Yamada Hideo
Yamada Apiculture Center Inc.
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