Direct Identification of a Novel Disulfide Bond Linkage System of New Isolated Isomer (Isomer V) in Recombinantly Produced h-IGF-I

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概要

• 論文の詳細を見る

• Insulin-like growth factor I (IGF-I or somatomedin C) is a serum polypeptide with three intramolecular disulfide bond. In the course of synthesis by the recombinant DNA method, three disulfide bond isomers, all of which have Cys^<18>-Cys^<61> with three combinations of two disulfide bonds formed by Cys^6,Cys^<47>, Cys^<48> and Cys^<52>, were identified. Natural type, isomer II, was proved to have a Cys^6-Cys^<48>, Cys^<18>-Cys^<61>, Cys^<47>-Cys^<52> disulfide bond system. Now, the fourth isomer, isomer V which doesn't have Cys^<18>-Cys^<61> disulfide, has been isolated, and its novel disulfide bond linkage system was identified by a chemical synthetic method. The supposed conformation constrained in 3D structure for isomer V would be discussed for its biological activity.

• 社団法人日本薬学会の論文
• 2000-09-01

著者

• 山田 治民

  (株) ディ・ディ・エス研究所

• Yamada H

  Yamada Apiculture Center Inc.

• Kobayashi M

  Fujisawa Pharmaceutical Co. Ltd. :(peresent Address)fujisawa Research Insitute Of America Inc. North

• IWAI Michio

  Marine Technical College

• YOKOYAMA Hideyuki

  Fujisawa Pharmaceutical Co., Ltd.,

• YAMADA Hisashi

  Fujisawa Pharmaceutical Co., Ltd.,

• KOBAYASHI Masakazu

  Fujisawa Pharmaceutical Co., Ltd.,

• Yokoyama H

  Osaka Pharmaceutical Association

• Niwa Mineo

  Pharmacological Research Laboratories And Exploratory Research Laboratories

• Niwa Mineo

  Institute For Medicinal Resources The University Of Tokushima

• Kobayashi M

  Faculty Of Pharmaceutical Sciences Osaka University

• Kobayashi Masao

  Pharmaceutical Research Laboratory Tanabe Seiyaku Co. Ltd.

• Kobayashi M

  Graduate School Of Pharmaceutical Sciences Osaka University

• Yamada H

  School Of Science And Technology Kwansei Gakuin University

• Niwa M

  Institute For Medicinal Resources The University Of Tokushima

• Iwai M

  Marine Technical College

• Yamada Harutami

  Drug Delivery System Institute Ltd.:(present Address)tanabe Seiyaku Co. Ltd.

• 小林 資正

  Graduate School Of Pharmaceutical Sciences Osaka University

• Kawaguchi M

  Graduate School Of Pharmaceutical Sciences Osaka University

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