New Methods Suitable for Large-Scale Preparation of Sialoglycosides
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概要
- 論文の詳細を見る
Facile method applicable for large-scale preparation of sialoglycosides were developed by using Lewis acid alone or the combination of trimethylsilyl chloride and lewis acid as the activator. Glycosylation catalyzed by zinc bromide using methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-β-D-glycero-D-glacto-2-nonulopyranosyl chlorid)onate as a glycosyl donor afforded predominantly α-sialoglycosides. In the reaction using methyl 5-acetamido-2,4,7,8,9-penta-O-acetyl-3,5-dideoxy-β-D-glycero-D-galacto-2-nonulopyranosonate as the glycosyl donor, with tin(IV) chloride as an activator, β-sialoglycosides were obtained stereoseloctively, whereas the combination of trimethylsilyl chloride and zinc triflate as an activator afforded predominantly α-sialoglycosides.
- 社団法人日本薬学会の論文
- 1992-09-25
著者
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山田 治民
Drug Delivery System Institute, Ltd., Bldg. of Research Institute for Biosciences, The Science Unive
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東 邦雄
Drug Delivery System Institute, Ltd., Bldg. of Research Institute for Biosciences, The Science Unive
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山田 治民
(株) ディ・ディ・エス研究所
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東 邦雄
東京理科大学生命科学研究所内 (株)ディ・ディ・エス研究所
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三好 詩郎
東京理科大学生命科学研究所内 (株)ディ・ディ・エス研究所
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中林 暁
東京理科大学生命科学研究所内 (株)ディ・ディ・エス研究所
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三好 詩郎
Drug Delivery System Institute, Ltd.,
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中林 暁
Drug Delivery System Institute, Ltd.,
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伊藤 幸雄
Drug Delivery System Institute, Ltd.,
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東 邦雄
Drug Delivery System Institute Ltd.
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伊藤 幸雄
Drug Delivery System Institute Ltd.
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Yamada H
Yamada Apiculture Center Inc.
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Yamada H
School Of Science And Technology Kwansei Gakuin University
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Yamada Harutami
Drug Delivery System Institute Ltd.:(present Address)tanabe Seiyaku Co. Ltd.
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