Cyclic Guanidines. III. Synthesis of Hypoglycemic 2-Benzhydrylimino-1,3-diazacycloalkanes

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概要

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• 2-Benzhydryliminoimidazolidine derivatives were prepared by the reactions of benzhydrylamines with 2-methylthio- or 2-chloro-2-imidazoline. The reaction of 1-benzhydryl-2-methylisothiourea or benzhydrylisocyanidedichloride with alkylenediamines gave the many 2-benzhydrylimino-1,3-diazacycloalkanes (14-21). Compound 14,15,and 17 were alkylated or acylated to give the ring nitrogen substituted derivatives. The alkyl or acyl derivatives of 2-benzhydryliminoimidazolidine obtained here have two tautomeric form, 2-amino and 2-imino form, which were discussed by use of the NMR spectral data. Some of 2-benzhydrylimino-1,3-diazacycloalkanes showed hypoglycemic activity.

• 社団法人日本薬学会の論文
• 1979-04-25

著者

• 東 邦雄

  Drug Delivery System Institute Ltd.

• 渡辺 好文

  Daiichi Pharmaceutical Co. Ltd. Research Institute

• 東 邦雄

  Research Institute, Daiichi Seiyaku Co., Ltd.,

• 小笹山 瑛

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 石川 文義

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 渡辺 好文

  Research Institute, Daiichi Seiyaku Co., Ltd.

• 石川 文義

  Research Institute Daiichi Seiyaku Co. Ltd.

• 小笹山 瑛

  第一製薬

• 小笹山 瑛

  Research Institute Daiichi Seiyaku Co. Ltd.

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