3,4-Dihydrothienopyrimidines. III. Alkylation of 2-Chloro-3,4,5,6,7,8-hexahydro [1] benzothieno [2,3-d] pyrimidines and Related New Heterocycles
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概要
- 論文の詳細を見る
Methylation of 2-chloro-3,4,5,6,7,8-hexahydro [1] benzothieno [2,3-d] pyrimidine (1) gave the 3-methyl derivative as a major product, but benzylation predominantly afforded the 1-substituted product. On the other hand, alkylation of 1 with an α-carbonylalkyl halide predominantly occurred at position 3. The 2-chloro-1-or 3-alkylated compounds were easily hydrolyzed to give the corresponding 1-alkyl-2 (1H)-or 3-alkyl-2 (1H)-one derivatives, which were readily oxidized to the corresponding 3,4-or 1,4-dehydrogenated compounds, respectively. The 2-chloro-3-substituted compounds were used for the synthesis of new heterocycles, imidazo [1,2-a] thieno [2,3-d] pyrimidine and 2,3-dihydro-5H-oxazolo [3,2-a] thieno [2,3-d]-pyrimidine.
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
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石川 文義
Research Institute, Daiichi Seiyaku Co., Ltd.
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山口 等
Research Institute Daiichi Pharmaceutical Co. Ltd.
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石川 文義
Research Institute Daiichi Seiyaku Co. Ltd.
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