Interactions between Synthetic Nucleotide Analogs and Snake Venom 5'-Nucleotidase

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概要

• 論文の詳細を見る
• 公益社団法人日本薬学会の論文
• 1961-04-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  Faculty Of Pharmacy Kanazawa University

• 水野 義久

  北海道大学 薬

• 上田 亨

  Faculty of Pharmaceutical Science, Hokkaido University

• 大塚 栄子

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 野村 哲士

  Faculty of Pharmaceutical Sciences Hokkaido University

• 石川 文義

  Research Institute Daiichi Seiyaku Co. Ltd.

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

• 石川 文義

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University, Sapporo, Hokkaido.

• 金井 良雄

  Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University, Sapporo, Hokkaido.

• 金井 良雄

  Chemical Research Laboratories Research & Development Division Takeda Chemical Industries Ltd.

関連論文

• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• 3.ビタミンB_補酵素のアデニン部修飾アナログの合成と補酵素機能(第293回会議研究発表要旨,ビタミンB研究委員会)
• Protecting Groups in Nucleosides and Nucleotides Synthesis. VIII. Synthesis of (4-Substituted 2-Picolyl 1-Oxide) halides and 2'-and 3'-O-(4-Substituted-2-picolyl 1-Oxide) nucleosides
• Studies on the Chemical Synthesis of Potential Antimetabolites. XXIV. The Synthesis and Antitumor Activities of p-Tosylhydrazones of 2-Formylpyridine 1-Oxides and 2-Formylazoles 3-Oxides
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• PHOSPHOLIPASE D-CATALYZED TRANS-ALKYLPHOSPHORYLATION : A FACILE ONE-STEP SYNTHESIS OF NUCLEOSIDE 5'-ALKYLPHOSPHATES
• Synthesis of Bredinin from 1-β-D-Ribofuranosyl-5-aminoimidazole-4-carboxamide by a Photo-Reaction
• Synthesis of 6,2'-Methano-cyclouridine, a Uridine Fixed in High-Anti Conformation (Nucleosides and Nucleotides. LX)
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Nucleosides and Nucleotides. CXIX. Inhibition of DNA-Cytosine Methylase Hha I by a Self-Complementary Oligonucleotide Containing 5-Fluorocytosine
• Improved Procedures for the Syntheses of Pyrido- and Pyrrolo[2,3-d]pyrimidines, and Ribosides Thereof
• Studies on Antitumor Agents. IX. : Synthesis of 3'-O-Benzyl-2'-deoxy-5-trifluoromethyluridine
• Pyrimidine S- and N-Cyclonucleosides. Synthesis of 6,2'(and 5')-S- and N-Cyclouridines (Nucleosides and Nucleotides. XXXII)
• Nucleosides and Nucleotides. IX. Synthesis of Sulfur-bridged Cyclonucleosides : (S)-2,2'-, 2,3'-, and 2,5'-Cyclo-2-thiouridines
• Synthesis of Sulfur-Bridged Uracil Anhydronucleosides
• The Photocycloaddition Reactions of Uridine and Related Compounds with 2,3-Dimethyl-2-butene
• Syntheses of Some Tricyclic Heterocycles from 5,6-Diamino-1,3-dimethyluracil
• Reaction of 5-Bromouridine Derivatives with Dimethyl Malonate Carbanion. A Novel Entry to the Synthesis of Uridine-5-acetic Acids
• Synthesis of 2'-Deoxy-6,2'-methano-cyclouridine (Nucleosides and Nucleotides. LIX)
• Nucleosides and Nucleotides. LIV. Synthesis of 6,6'-Cyclo-5', 6'-dideoxyhexofuranosyluracils via Radical Cyclization of a 6-Cyanouridine
• Introduction of Carbon Substituents into Pyrimidine and Purine Nucleosides by Sulfur Extrusion (Nucleosides and Nucleotides. XXX)
• Synthesis of 6,5'-S- and 6,5'-N-Cyclouridines (Nucleosides and Nucleotides. XXII)
• Synthesis of 6-Cyano- and 5-Cyano-uridines and Their Derivatives (Nucleosides and Nucleotides. XXI)
• Synthesis of 6-Cyanocytidine and Its Derivatives (Nucleosides and Nucleotides. XX
• Nucleosides and Nucleotides. XIV. Synthesis of 6-Alkylthiouridines and Uridine-6-sulfonic Acid
• Synthesis of Orotidine from Uridine
• THE DESIGN, SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF 5-ALKYNYL-1-β-D-RIBOFURANOSYLIMIDAZOLE-4-CARBOXAMIDES
• Substrate Specificity of a Thymidine Phosphorylase in Human Liver Tumor
• Synthesis of 2,4-Dithiouridine and 2-Thiocytidines
• Synthetic Studies of Potential Antimetabolites. XI. Syntheses of β-D-Pentofuranosyl-5-methylcytosines
• Alternative Synthesis of 2'-Deoxy-6,2'-methano-pyrimidine Nucleosides : Nucleosides and Nucleotides. XC
• Synthesis of 6,6'-Cyclo-5', 6'-dideoxy-1-(β-D-allofuranosyl)cytosine and Related Nucleosides : Nucleosides and Nucleotides.LXXXVIII)
• Synthesis of 6,3'-Methanocytidine, 6,3'-Methanouridine, and Their 2'-Deoxyribonucleosides (Nucleosides and Nucleotides. LXXVII)
• Preparation and Characterization of Monoclonal Antibodies Specific for Ribonuclese Inhibitor from Rat Liver
• Purification of Chicken Liver Ribonucleases by Affinity Chromatography with UMP-Sepharose (Nucleosides and Nucleotides. LII)
• Alkyl Addition Reaction of Pyrimidine 2'-Ketonucleosides : Synthesis of 2'-Branched-Chain Sugar Pyrimidine Nucleosides : Nucleosides and Nucleotides. LXXXI^1
• Syntheses of 7-Alkyl-1,3,6-trimethylpyrrolo[2,3-d]pyrimidines and 4-Alkylamino-2,5-dimethyl-2,3-dihydrofuro[3,2-e]pyrimidines
• A Series of Novel Acyclic Nucleosides. IV. Synthesis of N^1-Sulfur Analogues of Acyclovir, Directed toward Improved Antivial Activities
• A SERIES OF NOVEL ACYCLIC NUCLEOSIDES I : SYNTHESIS OF 5-AMINO-3-[(2-HYDROXYETHOXY)METHYL]-3H-IMIDAZO[4,5-d][1,3]OXAZIN-7-ONE
• Reactions of 1-(2-Acetoxyethoxy)methyl-5-amino-4-cyanoimidazole with Isothiocyanates
• A Convenient Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) and Related Compounds
• Studies Directed toward the Total Synthesis of Sinefungin. I. Synthesis of 4-(5'-Deoxyuridin-5'-yl)-4-nitrobutyronitrile, 4-(5'-Deoxyadenosin-5'-yl)-4-nitrobutyramide and Closely Related Nucleosides
• Studies on the Chemical Synthesis of Potential Antimetabolites. XXXIV. Apparent Discrepancy among Reported Proton Nuclear Magnetic Resonance Spectra of 3-Deazaadenosine Is Actually a Reflection of a Difference in Molecular Species
• Synthesis of (23R)-Calcidiol Lactone (25-Hydroxyvitamin D_3 26,23-Lactone)
• Studies on the Chemical Synthesis of Potential Antimetabolites. XXV. Synthesis of (±)-Isowillardiine by Application of a Four-Component Condensation involving 2-Picolylamine 1-Oxide and 2-Picolyl Isocyanide 1-Oxide
• 支部長を理事に併任させ理事会の重要な任務を分担させたら
• Nucleotides. VII. A Procedure for the Preparation of Diribonucleoside Monophosphates having Natural Linkage
• 8 生理活性アミノアシルユラシル類(イソビラルジイン、ポリオキシン)の合成研究
• Syntheses of Potential Antimetabolites. XX. Syntheses of 5-Carbomethoxymethyl-and 5-Methylaminomethyl-2-thiouridine (The "First Letters"of Some Anticodons) and Closely Related Nucleosides from Uridine
• Nucleotides. III. Syntheses of Deazaadenosine 3', 5'-Cyclic Phosphates and Related Nucleotides of Biological Interest
• Molecular Conformations of Carbon-Bridged Cyclodeoxyadenosines in the Solid State and in Solution.2'-Deoxy-8,2'-methanoadenosine and 2'-Deoxy-8,2'-ethanoadenosine
• Nucleosides and Nucleotides. XLIII. : On the Stereoselectivity of Alkyl Addition Reaction of Pyrimidine 2'-Ketonucleosides
• Crystal and Molecular Structures of Carbon-Bridged Pyrimidine Cyclonucleosides. Substrate Analogs of Ribonuclease A
• A NEW METHOD FOR SYNTHESIZING THE ANTINEOPLASTIC NUCLEOSIDES 1-(2-AZIDO-2-DEOXY-β-D-ARABINOFURANOSYL)CYTOSINE (CYTARAZID) AND 1-(2-AMINO-2-DEOXY-β-D-ARABINOFURANOSYL)CYTOSINE (CYTARAMIN) FROM URIDINE
• Synthesis and Optical Properties of 2'-Deoxy-8,2'-methanoguanosine
• A Facile Enzymatic Synthesis of 5'-(3-sn-Phosphatidyl)nucleosides and Their Antileukemic Activities
• Synthesis of 6,5'-Cyclo-5'-deoxy-5'(R and S)-(2-hydroxyethyl)-uridmes (Nucleosides and Nucleotides. LXXIII)(Organic,Chemical)
• Synthesis of 6,5'-Cyclo-2',5'-dideoxypyrimidine Nucleosides : Nucleosides and Nucleotides. LXXII(Organic,Chemical)
• The Reaction of 6-Phenylthiouridine with Sulfur Nucleophiles : A Simple and Regiospecific Preparation of 6-Alkylthiouridines and 6-Alkylthiouridylic Acids
• Potential Antimetabolites. IV. Synthesis of 2,6-Bis-alkylthiopurine Ribosides and their Selective Substitution by Nucleophilic Reagents.
• Syntheses of Potential Antimetabolites. XVII. New Type of Cyclo- and Keto-sugar-nucleosides. 7-(5-O-Trityl-2,3-dideoxy-2-oxo-α-D-pentofuranosyl)-and 5'-O-Trityl-3', 6-anhydro-7-α-D-arabinofuranosylhypoxanthine
• Synthesis of a Potential Antitumor Agent : 4-(β-D-Ribofuranosyl)-4,5,6,7-tetrahydrothiazolo [4,5-d] pyrimidine-5,7-dione (Thioanalog of 3-Isoxanthosine)
• Synthesis of Guanosine 5'-Diphosphate.
• Benzothiazoles. XII. : Studies on Reaction between 2-Chlorobenzothiazoles and Compounds possessing Reactive Methylene Groups.
• Structural Elucidation of Tubercidin
• Potential Antimetabolites. VI. An Improved Synthesis of 2-β-D-Ribofuranosyl-as-triazine-3,5 (2H, 4H)-dione (6-Azauridine).
• Potential Antimetabolites. II. Chemical Synthesis of 6-Azacytidine.
• Potential Antimetabolites. I. Selective Thiation of Uracil and 1,2,4-Triazine-3,5 (2H, 4H)-dione (6-Azauracil).
• Debenzylation Reaction of Benzylphosphoric Acid Esters
• Hydrogen Fluoride as an Agent in Organic Reactions. I. Degradation of Polynucleotides with Liquid Hydrogen Fluoride
• Nucleosides and Nucleotides. XXXXV. Facile Deoxygenation of Neplanocin A and Nucleosides by the Use of Tri-n-butyltin Hydride
• Synthesis of 2'-Substituted Derivatives of Neplanocin A (Nucleosides and Nucleotides. XLIV)
• Synthesis of 2'(R)-Substituted Neplanocin A's (Nucleosides and Nucleotides. XXXVII)
• Selective Acylation of the Amino or the Primary Hydroxyl Group of Cytidine
• Studies on condensed Systems of Aromatic Nitrogenous Series. XXIV. Synthesis of 4-Substituted 1H-Imidazo[4,5-c]pyridines
• Synthetic Studies of Potential Antimetabolites. VII. Evidences that the supposed 1-β-D-Ribofuranosyl-1H-imidazo [4,5-b] pyridine is actually 3-β-D-Ribofuranosyl-3H-imidazo [4,5-b] pyridine (1-Deazapurine Ribofuranoside)
• Synthesis and Optical Properties of 2,3-Dideoxy-D-erythro-hex-2-enopyranosyl Nucleosides (Nucleosides and Nucleotides. LXII)
• Degradation of Nucleic Acids with Ozone. IV. Specific Internucleotidic Bond-Cleavage of Ozone-Treated Transfer Ribonucleic Acids with Aniline-acetate
• Degradation of Nucleic Acids with Ozone. III. Mode of Ozone-Degradation of Mouse Proline Transfer Ribonucleic Acid (tRNA) and Isoleucine tRNA
• Degradation of Nucleic Acids with Ozone. I. Degradation of Nucleobases, Ribonucleosides and Ribonucleoside-5'-monophosphates
• Preparation of ^S-Labeled Ribonucleic Acid and Deoxyribonucleic Acid and Their Use for the Assay of Nucleolytic Enzymes (Nucleosides and Nucleotides. XXXIX)
• Modification of Cytosine Moieties of Nucleic Acids with Hydrogen Sulfide (Nucleosides and Nucleotides. XXXIV)
• Synthesis of 6-Thioguanine and 2,6-Diaminopurine Nucleosides and Nucleotides from Adenine Counterparts via a Facile Rearrangement in the Base Portion (Nucleosides and Nucleotides. XIX)
• Nucleosides and Nucleotides. XIII. Synthesis of Thiopurine Nucleosides from Adenosine and Guanosine Derivatives by the Sulfhydrolysis
• Chemical Conversion of Adenosine to Guanosine (Nucleosides and Nucleotides. XI)
• Nucleosides and Nucleotides. X. Synthesis of 4-Thiouracil Nucleosides and Nucleotides by the Solvolysis of Cytidine and Its Phosphates with Hydrogen Sulfide
• Nucleosides and Nucleotides. VIII. Formation of Spongocytidylyladenosine in the Synthesis of Cytidylyladenosine from Cytidine 2', 3'-Cyclic Phosphate and Adenosine
• Reaction of 6-Methylsulfonylpurine Riboside with Carbon Nucleophiles and the Synthesis of 6-Alkylpurine Nucleosides (Nucleosides and Nucleotides. XXIX)
• A New Protecting Group. IV. Syntheses of Several (2-Picolyl 1-oxide) thio Derivatives by Use of a New Thiol Group Reagent : 2-Picolylchloride 1-Oxide
• Synthesis of 2,4-Dithiouridine and 2-Thiocytidine
• A Convenient Synthesis of Ribonucleoside 2', 3', -Cyclic Phosphates from Ribonucleosides and Ribonucleotides
• Interactions between Synthetic Nucleotide Analogs and Snake Venom 5'-Nucleotidase
• A New and Convenient Synthesis of 1-O-Acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose from Guanosine ; Some Observations on Solvolysis of 2', 3', 5'-Tri-O-benzoylguanosine
• 異項双環化合物に関する研究(第13報) : マロン酸合成の異項環系への拡張
• Synthetic Studies of Potential Antimetabolites. XII. Synthesis of 4-Substituted 1-(β-D-Ribofuranosyl)-1H-imidazo [4,5-c] pyridines
• Potential Antimetabolites. V. The Syntheses of 4-, 5-, and 6-Nitrobenzimidazole Ribofuranosides.
• α-ピコリル1-オキシド基を用いる有機合成
• Conversion of Uridine into Isouramil Nucleosides and Related Reactions
• Reactions of Uracil Derivatives with Phenylhydrazine

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