Degradation of Nucleic Acids with Ozone. I. Degradation of Nucleobases, Ribonucleosides and Ribonucleoside-5'-monophosphates
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概要
- 論文の詳細を見る
The degradation of nucleobases, ribonucleosides and ribonucleotides with ozone was examined as a model of the action of ozone on nucleic acids. The degradation rates of nucleobases were in the following order : G, T>U>C>A. Nucleosides and nucleotides were degraded in the same order as in the corresponding nucleobases. The ribose moiety was degraded more slowly than the base portion in nucleosides and nucleotides except in the cases of adenosine and AMP. The degradation of D-ribose and D-ribose-5-phosphoric acid (R5P) was also examined, and it was found that R5P resisted the attack of ozone. Inorganic phosphate was liberated after the degradation of the ribose moiety.
- 公益社団法人日本薬学会の論文
- 1981-03-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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神力 就子
北海道工開試
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神力 就子
工技院北海道工業開発試験所
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石崎 紘三
Government Industrial Development Laboratory, Hokkaido
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神力 就子
Government Industrial Development Laboratory, Hokkaido
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上田 亨
北海道大学薬学部
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池畑 昭
Government Industrial Development Laboratory, Hokkaido
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