Chemical Conversion of Adenosine to Guanosine (Nucleosides and Nucleotides. XI)
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概要
- 論文の詳細を見る
A versatile chemical conversion of adenosine to guanosine is described. Treatment of adenosine-1-oxide with cyanogen bromide afforded hydrobromide salt of 2-imino-6-β-D-ribofuranosyl-(1,2,4-oxadiazolo [2,3-f] purine), which existed as N^6-cyanoadenosine-1-oxide on neutralization. Methylation of the latter followed by treatment with alkali afforded N^6-methoxy-2-aminoadenosine. The solvolysis of the product with liquid hydrogen sulfide gave 6-thioguanosine in high yield. Thioguanosine can be oxidatively hydrolyzed to guanosine by the known procedure. Catalytic hydrogenation of the oxadiazolopurine riboside in the presence of acetic acid gave 6-ureidopurine riboside.
- 公益社団法人日本薬学会の論文
- 1975-02-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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三浦 一伸
Faculty of Pharmaceutical Sciences, Hokkaido University
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三浦 一伸
Faculty Of Pharmaceutical Sciences Hokkaido University
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笠井 嗣夫
Faculty of Pharmaceutical Sciences, Hokkaido University
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笠井 嗣夫
Faculty Of Pharmaceutical Sciences Hokkaido University
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