Nucleosides and Nucleotides. XXXXV. Facile Deoxygenation of Neplanocin A and Nucleosides by the Use of Tri-n-butyltin Hydride

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概要

• 論文の詳細を見る

• 2'(R)-Halogeno-2'-deoxyneplanocin A's were hydrogenated with tri-n-butyltin hydride to yield 2'-deoxyneplanocin A. The same compound was obtained by reduction of the 2'-O-(1-imidazolyl) thiocarbonyl derivative of neplanocin A. This procedure was also applicable to the synthesis of 2'-deoxyadenosine and-guanosine from the corresponding ribosides. Treatment of a neplanocin 2', 3'-O-cyclic thiocarbonate with tri-n-butyltin hydride gave 3'-deoxyneplanocin selectively in high yield.

• 公益社団法人日本薬学会の論文
• 1983-06-25

著者

• 上田 亨

  Faculty of Pharmaceutical Science, Hokkaido University

• 上田 亨

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 平野 孝夫

  Research Laboratories, Toyo Jozo Co., Ltd.,

• 福川 清史

  Reseach Laboratories Toyo Jozo Co. Ltd.

• 上田 亨

  北海道大学薬学部

• 福川 清史

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 平野 孝夫

  Research Laboratories Toyo Jozo Co. Ltd.

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