Debenzylation Reaction of Benzylphosphoric Acid Esters

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概要

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• Various para-substituted benzyl phosphates were subjected to debenzylation reaction with sodium iodide in acetone or methyl ethyl ketone. Reaction of para-substituted benzyl diphenylphosphates was investigated kinetically and relative easiness of debenzylation was found to be in the decreasing order of p-nitro-, p-bromo-, unsubstituted, and p-methyl-benzyl groups. Evidences for S_<N2> mechanism are described.

• 公益社団法人日本薬学会の論文
• 1960-08-25

著者

• 池原 森男

  Faculty of Pharmaceutical Sciences, Osaka University(Present address)

• 上田 亨

  Faculty of Pharmaceutical Science, Hokkaido University

• 渡辺 恭一

  Sloan-kettering Instiute For Cancer Research Memorial Sloan-kettering Cancer Center:sloan-kettering

• 渡辺 恭一

  Faculty of Pharmaceutical Sciences Hokkaido University, School of Medicine

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

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