Polynucleotides. LIII. Conformation of Dinucleoside Monophosphates containing 8-Methyladenosine Residue as studied by Proton Magnetic Resonance
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概要
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Conformation of dinucleoside monophosphates containing 8-methyladenosine (m^8A) residue, which prefer a syn conformation, was analyzed by proton magnetic resonance studies. The dimers are 2'-5' and 3'-5' isomers of Apm^8A, and m^8Apm^8A. The following results were obtained. The data for (2'-5') Apm^8A are consistent with an anti (2')-anti (5'), right-handed stacked conformation. The data for (3'-5') Apm^8A are consistent with a syn (3')-syn (5') and a high anti (3')-high anti (5') stacked conformation. The data for (3'-5') m^8Apm^8A can be explained by a syn (3')-syn (5') conformation with little stacking. The data for (2'-5') m^8Apm^8A can be explained by an anti (2')-syn (5') stacked conformation. These results are in accordance with the results of ultraviolet and circular dichroism studies.
- 社団法人日本薬学会の論文
- 1978-12-25
著者
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上杉 晴一
横浜国立大学工学部
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上杉 晴一
Faculty Of Engineering Yokohama National University
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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林 元吉
Faculty of Pharmaceutical Sciences, Osaka University
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上杉 精一
Faculty Of Pharmaceutical Sciences Osaka University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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林 元吉
Faculty Of Pharmaceutical Sciences Osaka University
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上杉 晴一
Faculty Of Pharmaceutical Sciences Osaka University
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