Studies on Transfer Ribonucleic Acids and Related Compounds. XLIII. Synthesis of Oligoribonucleotides by using 5'-Selective Phosphorylation of 2'-O-Tetrahydrofuranyl Nucleosides
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概要
- 論文の詳細を見る
2'-O-Tetrahydrofuranyl nucleosides have been synthesized from 2,3-dihydrofuran via 3', 5'-bis-tert-butyldimethylsilylnucleosides. These nucleosides were used as intermediates for oligonucleotide syntheses by the phosphotriester method. Trimers C-C-A and C-C-U were synthesized by the stepwise addition of monomers. U-U-U-U-U-U, A-U-G-A-U-G and A-U-G-A-U-G-A-U-G were obtained by the block condensation of trimers in which the 5'-hydroxyl group had been selectively phosphorylated.
- 社団法人日本薬学会の論文
- 1983-05-25
著者
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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大塚 栄子
Faculty of Pharmaceutical Sciences, Osaka University
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大塚 栄子
Faculty Of Pharmaceutical Sciences Hokkaido University
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山根 明男
Faculty of Pharmaceutical Sciences, Osaka University
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山根 明男
Faculty Of Pharmaceutical Sciences Osaka University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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