Studies on Coenzyme Analogs. XIII. Oxidation of Methylmercaptopurine and its Nucleoside by means of N-Chloro-and N-bromosuccinimide.
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概要
- 論文の詳細を見る
The methylmercapto group situated on the 2-or 6-position of purine and purine nucleoside was readily oxidized to methylsulfonyl group by treatment with N-chlorosuccinimide. In this reaction unprotected nucleoside occasionally caused the cleavage of nucleoside linkage. N-Bromosuccinimide could also be used for replacement of methylmercapto to amino or hydroxy group by successive treatment of the intermediate with water or ammonia.
- 公益社団法人日本薬学会の論文
- 1962-11-25
著者
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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山崎 晤弘
Central Research Laboratories Ajinomoto Co. Inc.
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山崎 晤弘
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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藤枝 聰子
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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藤枝 聰子
Faculty Of Pharmaceutical Sciences School Of Medicine Hokkaido University
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