Selective Removal of Protecting Groups for Phosphomonoesters of Nucleotides by Anodic Oxidation

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概要

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• Cyclic volutammetry of phenyl derivatives of various nucleotides was carried out, using the parent nucleosides as a control. The p-N-benzylaminophenyl ester of 3'-O-acetylthymidine 5'-phosphate showed a peak at low anodic potential, and the N-benzyl-aminophenyl group could be removed by controlled potential electrolysis at this potential. p-N-Tritylaminophenyl-, p-N-acetylaminophenyl and p-methoxyphenyl esters of nucleotides were also subjected to controlled potential electrolysis ; the oxidative removal of these phenyl groups was less effective than that of the N-benzylaminophenyl ester.

• 公益社団法人日本薬学会の論文
• 1979-09-25

著者

• 池原 森男

  Faculty of Pharmaceutical Sciences, Osaka University(Present address)

• 大塚 栄子

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 大森 秀信

  Faculty of Pharmaceutical Sciences, Osaka University

• 大森 秀信

  Faculty Of Pharmaceutical Sciences Osaka University

• 三宅 哲男

  Faculty Of Pharmaceutical Sciences Osaka University

• 池原 森男

  Faculty Of Pharmaceutical Sciences Osaka University

• 松本 晃暎

  Faculty of Pharmaceutical Sciences, Osaka University

• 松本 晃暎

  Faculty Of Pharmaceutical Sciences Osaka University

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