Potential Antimetabolites. I. Selective Thiation of Uracil and 1,2,4-Triazine-3,5 (2H, 4H)-dione (6-Azauracil).
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概要
- 論文の詳細を見る
1,2,4-Triazine-3,5 (2H, 4H)-dione (6-azauracil) (I ; R=H) and uracil were partially thiated to afford 5-mercapto-1,2,4-triazin-3 (2H)-one (II ; R=H) and 4-mercapto-2 (1H)-pyrimidinone, respectively, in good yields by the use of limited amount of phosphorus pentasulfide. These are the first examples of the success of monothiation in triazine and pyrimidine series. The alkylation of 5-mercapto-1,2,4-triazin-3 (2H)-one gave the corresponding alkylthio derivatives (IV and V ; R=H) from which 5-amino-1,2,4-triazin-3 (2H)-one (6-az-acytosine) (III ; R=H) was synthesized in an excellent yield.
- 公益社団法人日本薬学会の論文
- 1962-08-25
著者
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水野 義久
School Of Pharmaceutical Sciences Kitasato University
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水野 義久
Faculty Of Pharmacy Kanazawa University
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水野 義久
北海道大学 薬
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池原 森男
Faculty of Pharmaceutical Sciences, Osaka University(Present address)
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渡辺 恭一
Sloan-kettering Instiute For Cancer Research Memorial Sloan-kettering Cancer Center:sloan-kettering
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渡辺 恭一
Faculty of Pharmaceutical Sciences Hokkaido University, School of Medicine
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池原 森男
Faculty Of Pharmaceutical Sciences Osaka University
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