8 生理活性アミノアシルユラシル類(イソビラルジイン、ポリオキシン)の合成研究

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概要

• 論文の詳細を見る

• The present report deals with the synthesis of isowillardiine (II) and the polyoxin skeleton which have the α-aminouracil structure in common, by the four-component (aldehyde, isocyanide, amine, and organic oxyacid) condensation (Ugi reaction). This reaction permited us to synthesize the above structure (in their protected forms) in one step starting from the corresponding aldehyde. Removal of the protecting group in VIII under conditions of 9N HCl-48 hr afforded isowillardiine, whereas many attempts at complete removal of the protection to XVI is not rewarding, yet.

• 天然有機化合物討論会の論文
• 1976-09-20

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  北海道大学 薬

• 池田 一芳

  The Center for Instrumental Analysis of Hokkaido University

• 土田 清美

  北海道大学薬学部

• 池田 一芳

  北海道大学薬学部

• 池田 一芳

  北海道大学機器分析センター

• 土田 清美

  Faculty Of Pharmaceutical Sciences Hokkaido University

関連論文

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• Protecting Groups in Nucleosides and Nucleotides Synthesis. VIII. Synthesis of (4-Substituted 2-Picolyl 1-Oxide) halides and 2'-and 3'-O-(4-Substituted-2-picolyl 1-Oxide) nucleosides
• Studies on the Chemical Synthesis of Potential Antimetabolites. XXIV. The Synthesis and Antitumor Activities of p-Tosylhydrazones of 2-Formylpyridine 1-Oxides and 2-Formylazoles 3-Oxides
• Improved Procedures for the Syntheses of Pyrido- and Pyrrolo[2,3-d]pyrimidines, and Ribosides Thereof
• The Photocycloaddition Reactions of Uridine and Related Compounds with 2,3-Dimethyl-2-butene
• Syntheses of Some Tricyclic Heterocycles from 5,6-Diamino-1,3-dimethyluracil
• Synthesis of 2,4-Dithiouridine and 2-Thiocytidines
• Synthetic Studies of Potential Antimetabolites. XI. Syntheses of β-D-Pentofuranosyl-5-methylcytosines
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• 8 生理活性アミノアシルユラシル類(イソビラルジイン、ポリオキシン)の合成研究
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