Nucleotides. VII. A Procedure for the Preparation of Diribonucleoside Monophosphates having Natural Linkage
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概要
- 論文の詳細を見る
A procedure has been devised whereby out of a pair of 2'-5'-and 3'-5'-positional isomers of 2-thiouridylyl- and uridylyluridine derivatives, the former could be selectively cleaved into halves through the 2,2'-anhydronucleoside formation so that the isolation of the dinucleoside monophosphate having natural linkage may become easier. In this connection, conditions for selective 2,2' anhydro-bond formation have been examined and 2-(t-butoxycarbonyl) phenyl group has been introduced as a protecting group for the phosphate of dinucleoside monophosphates (e.g., 8c and 9c). A simple procedure for the synthesis of 2,2'-(S)-anhydro-2-thiouridylyl-(3'-5')-uridine was also described.
- 社団法人日本薬学会の論文
- 1976-12-25
著者
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水野 義久
School Of Pharmaceutical Sciences Kitasato University
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水野 義久
Faculty Of Pharmacy Kanazawa University
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水野 義久
北海道大学 薬
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佐藤 盛幸
Faculty of Pharmaceutical Sciences, Hokkaido University
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佐藤 盛幸
Faculty Of Pharmaceutical Sciences Hokkaido University
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