A Convenient Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) and Related Compounds

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概要

• 論文の詳細を見る

• A convenient and economical synthesis of 9-(2-hydroxyethoxymethyl)guanine (1,acyclovir, Zovirax, or acyclic guanosine : an antiherpetic agent)from guanine was developed via N^2,O-diacetylacyclovir. Two closely related compounds, N^2-acetylacyclovir (7) and O-acetylacyclovir (8), were also prepared by selective deacetylation.

• 社団法人日本薬学会の論文
• 1988-03-25

著者

• 松本 広淳

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 森 武雄

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  北海道大学 薬

• 山田 敬子

  Research Laboratory Minophagen Pharmaceutical Co.

• 金子 千里

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 竹内 惟雄

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 水野 義久

  Research Laboratory, Minophagen Pharmaceutical Co.,

• 森 武雄

  Research Laboratory Minophagen Pharmaceutical Co.

• 松本 広淳

  Research Laboratory Minophagen Pharmaceutical Co.

• 竹内 惟雄

  Research Laboratory Minophagen Pharmaceutical Co.

• 金子 千里

  Research Laboratory Minophagen Pharmaceutical Co.

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