Synthesis of 2,4-Dithiouridine and 2-Thiocytidines

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概要

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• Starting from 2,4-dithio-1-methyluracil (II) various 1-methylpyrimidines were obtained through the intermediate pyrimidine (III). Some comparisons were made on the methylation of oxo- and thio-pyrimidines. A protected 4-thiouridine (XIII) afforded 2,4-dithiouridine (XV) by the direct thiation with phosphorus pentasulfide at elevated temperature and subsequent deblocking. 2-Thiocytidines were prepared from XV and the possible tautomeric form of 2-thiocytidine was discussed by the UV spectral behaviors.

• 1968-09-25

著者

• 水野 義久

  School Of Pharmaceutical Sciences Kitasato University

• 水野 義久

  Faculty Of Pharmacy Kanazawa University

• 水野 義久

  北海道大学 薬

• 上田 享

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 池田 一芳

  The Center for Instrumental Analysis of Hokkaido University

• 池田 一芳

  Faculty of Pharmaceutical Sciences, Hokkaido University

• 上田 享

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 飯田 幸此古

  Faculty Of Pharmaceutical Sciences Hokkaido University

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