Synthesis of 6,5'-Cyclo-5'-deoxyuridines by Radical Cyclization : Nucleosides and Nucleotides. L
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概要
- 論文の詳細を見る
6,5'-Cyclo-5'-deoxyuridine, a fixed anti form of uridine, was synthesized by a radical cyclization of 5'-bromo (or iodo)-5'-deoxy-2', 3'-O-isopropylidene-5-chloro (or bromo)-uridine with tri-■-butyltin hydride followed by dehydrohalogenation and deacetonation. The 5-bromo and 4-thio derivatives of the cyclouridine were also prepared and were converted to the 2', 3'-cyclic phosphates. These nucleotides were hydrolyzed by pancreatic ribonuclease. The result showed that the enzyme recognizes the pyrimidine nucleotides in the anti form. 6,5'-Cyclo-5'-deoxycytidine was also synthesized by two routes.
- 社団法人日本薬学会の論文
- 1984-09-25
著者
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周東 智
Research Laboratories Toyo Jozo Co. Ltd
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周東 智
Faculty of Pharmaceutical Sciences, Hokkaido University
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井上 英夫
Faculty of Pharmaceutical Sciences, Hokkaido University
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上田 享
Faculty of Pharmaceutical Sciences, Hokkaido University
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碓井 博幸
Faculty of Pharmaceutical Sciences, Hokkaido University
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井上 英夫
北海道大学薬学部
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碓井 博幸
Daiichi Pharmaceutical Co., Ltd.,
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碓井 博幸
Daiichi Pharmaceutical Co. Ltd.
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上田 享
Faculty Of Pharmaceutical Sciences Hokkaido University
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井上 英夫
Faculty Of Pharmaceutical Sciences Hokkaido University
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