A Facile Enzymatic Synthesis of 5'-(3-sn-Phosphatidyl)nucleosides and Their Antileukemic Activities

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概要

• 論文の詳細を見る

• Phospholipase D from Streptomyces effectively catalyzed the transfer reaction of the phosphatidyl residue from 3-sn-phosphatidylcholine to the 5'-hydroxyl group of nuclesides in a two-phase system. Thus, a variety of 5'-(3-sn-phosphatidyl)nucleosides could be readily prepared in high yields by means of this reaction. Among them, phosphatidyl-FUR (3b), phosphatidyl-Ara FC (8b), and phoshatidyl-neplanocin A (12b) each produced a significant increase in the life span mice bearing i.p.-implanted P388 leukemia, being more effective than the parent nucleosides.

• 公益社団法人日本薬学会の論文
• 1988-01-25

著者

• 上田 亨

  Faculty of Pharmaceutical Science, Hokkaido University

• 松田 彰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 上田 亨

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 周東 智

  北海道大学大学院薬学研究院

• 周東 智

  Research Laboratories Toyo Jozo Co. Ltd

• 今村 茂行

  Research Laboratories, Toyo Jozo Co., Ltd,

• 福川 清史

  Research Laboratories, Toyo Jozo Co., Ltd,

• 今村 茂行

  旭化成ファーマ

• 福川 清史

  Reseach Laboratories Toyo Jozo Co. Ltd.

• 伊東 裕通

  旭化成工業ライフサイエンス総合研究所

• 上田 亨

  北海道大学薬学部

• 伊東 裕通

  Reseach Laboratories, Toyo Jozo Co., Ltd.,

• 植田 成

  Reseach Laboratories, Toyo Jozo Co., Ltd.,

• 辻野 正俊

  Reseach Laboratories, Toyo Jozo Co., Ltd.,

• 植田 成

  旭化成ファーマ

• 辻野 正俊

  Reseach Laboratories Toyo Jozo Co. Ltd.

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