Synthesis and Optical Properties of 2,5'-O-Cycloimidazole Nucleosides and Related Compounds (Nucleosides and Nucleotides. XXV)
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概要
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Starting from 1-β-D-ribofuranosyl-2-oxo-4-imidazoline-4-carboxylic acid (1), obtained from uridine, various 2,5'-O-cycloimidazole nucleosides have been prepared. The 2-oxo function of 1 was also converted to the 2-chloro and 2-thione functions. Whereas the circular dichroism (CD) spectra of 1 and related 2-oxo derivatives exhibited negative bands, their 5-bromo derivatives showed positive bands. All 2,5'-O-cycloimidazole nucleosides showed strong negative CD bands which were in contrast to the results in the 8,5'-O-cyclopurine nucleosides. The relationship between the sign of the CD bands and the orientation of the base moieties in imidazole nucleosides was discussed.
- 公益社団法人日本薬学会の論文
- 1978-11-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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上田 亨
北海道大学薬学部
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田中 博道
Faculty Of Pharmaceutical Sciences Hokkaido University
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高橋 隆子
Faculty Of Pharmaceutical Sciences Hokkaido University
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富樫 浩之
Faculty of Pharmaceutical Sciences, Hokkaido University
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富樫 浩之
Faculty Of Pharmaceutical Sciences Hokkaido University
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