Nucleosides and Nucleotides. X. Synthesis of 4-Thiouracil Nucleosides and Nucleotides by the Solvolysis of Cytidine and Its Phosphates with Hydrogen Sulfide
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概要
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Treatment of cytidine with liquid hydrogen sulfide-pyridine afforded 4-thiouridine in an excellent yield. Similar treatment of sodium cytidine 5'-phosphate, cytidine 5'-diphosphate (CDP), cytidine 5'-triphosphate (CTP), and CDP-choline afforded the respective 4-thiouridine phosphates. In the case of CDP and CTP the hydrolytic cleavage of pyrophosphate linkage was noticed. Several cytidine derivatives such as arabinofuranosylcytosine, 3-methylcytidine, and 2-thiocytidine also underwent sulfhydrolysis affording respective 4-thio derivatives. The present method seemed to be the most versatile procedure for the synthesis of-4 thiouracil nucleosides and nucleotides.
- 公益社団法人日本薬学会の論文
- 1974-10-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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三浦 一伸
Faculty of Pharmaceutical Sciences, Hokkaido University
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三浦 一伸
Faculty Of Pharmaceutical Sciences Hokkaido University
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今沢 正興
Faculty of Pharmaceutical Sciences, Hokkaido University
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小田島 圭子
Faculty of Pharmaceutical Sciences, Hokkaido University
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小田島 圭子
Faculty Of Pharmaceutical Sciences Hokkaido University
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