Synthesis of 6,5'-S- and 6,5'-N-Cyclouridines (Nucleosides and Nucleotides. XXII)
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概要
- 論文の詳細を見る
Treatment of 5'-acetylthio-5'-deoxy-2', 3'-O-isopropylidene-5-bromouridine, prepared from 2', 3'-O-isopropylidene-5-bromouridine, with sodium methoxide in methanol afforded 5'-deoxy-5'-thio-2', 3'-O-isopropylidene-S^6,5'-cyclouridine. Deacetonation of the product gave 5'-deoxy-5'-thio-S^6,5'-cyclouridine, a sulfur-bridged cyclouridine fixed in the"anti"conformation. Starting from the 5'-amino derivative a N^6,5'-cyclouridine was similarly prepared. The nuclear magnetic resonance and mass spectra of a series of O-, N- and S-cyclouridines were compared and the characteristic features were discussed.
- 社団法人日本薬学会の論文
- 1978-09-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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井上 英夫
Faculty of Pharmaceutical Sciences, Hokkaido University
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井上 英夫
北海道大学薬学部
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上田 亨
北海道大学薬学部
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井上 英夫
Faculty Of Pharmaceutical Sciences Hokkaido University
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