Synthesis of 6,5'-Cyclo-2',5'-dideoxypyrimidine Nucleosides : Nucleosides and Nucleotides. LXXII(Organic,Chemical)
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概要
- 論文の詳細を見る
6,5'-Cyclo-2',5'-dideoxyuridine and 6,5'-cydo-5'-deoxythymidine, pyrimidine deoxynucleosides fixed in the and conformation, were synthesized. The key intermediate, 3'-O-acetyl-5-chloro-2',5'-dideoxy-5'-iodouridine (12), prepared from 2'-deoxyuridine, was cyclized by treatment with tributyltin hydride to the 6,5'-cyclo derivative (13), then dehydrochlorinated to furnish, after de-O-acetylation, 6,5'-cyclo-2',5'-dideoxyuridine (14). For the synthesis of 6,5'-cyclothymidine, 3'-O-acetyl-2',5'-dideoxy-5'-iodo-5-phenylthiomethyluridine (22) was prepared from 2'-deoxyuridine and this compound was cyclized by treatment with tributyltin hydride to yield, after de-O-acetylaion, 6,5'-cyclo-5'-deoxythymidine (24).
- 公益社団法人日本薬学会の論文
- 1987-03-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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松田 彰
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
Faculty Of Pharmaceutical Sciences Hokkaido University
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鈴木 ゆかり
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
北海道大学薬学部
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