A SIMPLIFIED SYNTHESIS OF 8-SUBSTITUTED PURINE NUCLEOSIDES VIA LITHIATION OF 6-CHLORO-9-(2,3-O-ISOPROPYLIDENE-β-D-RIBOFURANOSYL) PURINE

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概要

• 論文の詳細を見る

• 6-Chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl) purine (1) was found to be a suitable substrate for the preparation of C-8 substituted purine nucleosides. Thus, upon lithiation of 1 with LDA and successive reaction with various types of electrophiles, the C-8 substituted products were obtained. The C-6 chlorine atoms in these products were readily replaced by an amino group, a mercapto group, or hydrogen, providing a facile preparation of 8-substituted adenosines, 6-thioinosines, or nebularines.

• 公益社団法人日本薬学会の論文
• 1983-02-25

著者

• 田中 博道

  School of Pharmaceutical Sciences, Showa University

• 宮坂 貞

  School of Pharmaceutical Sciences, Showa University

• 松田 彰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 内田 祐子

  School Of Pharmaceutical Sciences Showa University

• 宮坂 貞

  昭和大学大学院薬学研究科医療薬学専攻

• 早川 弘之

  School of Pharmaceutical Sciences, Showa University

• 宮坂 貞

  School Of Pharmaceutical Sciences Showa University

• 松田 彰

  School of Pharmaceutical Sciences, Showa University

• 篠崎 操

  School of Pharmaceutical Sciences, Showa University

• 篠崎 操

  School Of Pharmaceutical Sciences Showa University

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