Studies on Heterocyclic Compounds. XIX. The Reaction of the Thiazolo [3,2-b] pyridazinium Perchlorates with Carbanions
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概要
- 論文の詳細を見る
On reaction with sodium salts of such active methylene compounds as ethyl cyanoacetate, malononitrile, ethyl malonate and phenylacetonitrile, thiazolo [3,2-b] pyridazinium perchlorates (I) furnish anhydro-8-(α, α-disubstituted methylene)-5,8-dihydrothiazolo [3,2-b]-pyridazinium hydroxides (IV, V, VI, and VII). On treatment with sodium hydrosulfide as a nucleophile, I affords anhydro-8-mercaptothiazolo [3,2-b] pyridazinium hydroxide (X). The reaction is initiated by the nucleophilic addition of the reagents at the 8-position, and subsequent oxidation by atmospheric oxygen via radical intermediates gives rise to the ylide compounds.
- 公益社団法人日本薬学会の論文
- 1982-01-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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佐藤 和恵
School Of Pharmaceutical Sciences Showa University
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佐藤 和恵
昭和大学薬学部分析センター
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佐藤 和恵
昭和大学院薬
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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荒川 基一
School of Pharmaceutical Sciences, Showa University
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荒川 基一
School Of Pharmaceutical Sciences Showa University
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