Direct C-8 Lithiation of Naturally-Occurring Purine Nucleosides. A Simple Method for the Synthesis of 8-Carbon-Substituted Purine Nucleosides(Organic,Chemical)
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概要
- 論文の詳細を見る
The sugar moiety of adenosine, inosine, or guanosine was protected with a tert-butyldimethyl-silyl group. The C-8 lithiation of these protected nucleosides was carried out with lithium diisopropylamide in tetrahydrofuran at below -70℃. The reactions of the C-8-lithiated species with Mel. HCO_2Me, and ClCO_2Me were examined. The resulting products having a carbon substituent at the C-8 position were converted to the corresponding 8-carbon-substituted purine nucleosides by treatment with tetrabutylammonium fluoride. The whole sequence constitutes a simple method for the preparation of 8-carbon-substituted purine nucleosides from intact purine nucleosides.
- 公益社団法人日本薬学会の論文
- 1987-01-25
著者
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田中 博道
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
昭和大学大学院薬学研究科医療薬学専攻
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早川 弘之
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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原口 一広
School of Pharmaceutical Sciences, Showa University
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