REACTION OF URACIL NUCLEOSIDES WITH 1-METHYLIMIDAZOLE IN THE PRESENCE OF PHOSPHORYL CHLORIDE : A CONVENIENT METHOD FOR THE SYNTHESIS OF 4-SUBSTITUTED PYRIMIDIN-2 (1H)-ONE NUCLEOSIDES

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概要

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• Reaction of 2', 3', 5'-tri-O-benzoyluridine (3) with 1-methylimidazole in the presence of phosphoryl chloride in acetonitrile afforded 3-methyl-1-imidazolium intermediate (4), from which a variety of 4-substituted pyrimidin-2 (1H)-one ribosides (5-12) were obtained in a one-pot manner by nucleophilic substitutions under mild conditions. Application of this method to 2'-deoxyriboside of several pyrimidines (13a, b, c) is also described.

• 公益社団法人日本薬学会の論文
• 1985-06-25

著者

• 宮坂 貞

  School of Pharmaceutical Sciences, Showa University

• 松田 彰

  Faculty Of Pharmaceutical Sciences Hokkaido University

• 宮坂 貞

  昭和大学大学院薬学研究科医療薬学専攻

• 宮坂 貞

  School Of Pharmaceutical Sciences Showa University

• 松田 彰

  School of Pharmaceutical Sciences, Showa University

• 小尾 紀行

  School of Pharmaceutical Sciences, Showa University

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