Synthesis of 2-Substituted 2,6-Dihydro-3-hydroxy-7H-pyrazolo [4,3-d] pyrimidin-7-ones
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概要
- 論文の詳細を見る
2-Substituted 2,6-dihydro-3-hydroxy-7H-pyrazolo [4,3-d] pyrimidin-7-ones bearing a methyl, phenyl, p-tolyl, m-tolyl or p-chlorophenyl group at the 2-position were synthesized by the reduction of ethyl 4-nitroso-5-hydroxy-1H-pyrazole-3-carboxylates and subsequent condensation of the resulting ethyl 4-amino-5-hydroxy-1H-pyrazole-3-carboxylates with formamide. Ethyl 4-nitroso-5-hydroxy-1H-pyrazole-3-carboxylates were prepared by nitrosation of ethyl 5-hydroxy-1H-pyrazole-3-carboxylates, which were derived from diethyl oxalacetate and monosubstituted hydrazines such as methyl-, phenyl-, p-tolyl-, m-tolyl-, and p-chlorophenylhydrazines.
- 公益社団法人日本薬学会の論文
- 1983-04-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
昭和大学大学院薬学研究科医療薬学専攻
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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越智 久雄
School of Pharmaceutical Sciences, Showa University
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越智 久雄
School Of Pharmaceutical Sciences Showa University
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