Studies of Heterocyclic Compounds. VII. The Reactions of 5,6-Dihydrothiazolo [2,3-b] thiazolium Salts with Carbanions
スポンサーリンク
概要
- 論文の詳細を見る
The reaction of 5,6-dihydrothiazolo [2,3-b] thiazolium salt (1) with the sodium salt of acetylacetone furnished 3-(2-thiazolyl)-acetylacetone (2) with elimination of thiirane and 2-acetonylidene-3-acetylthioethyl-4-thiazoline (3). The reaction of 1 with the sodium salt of ethyl acetoacetate gave ethyl 2-(2-thiazolyl)-acetoacetate (12) and the reaction of 1 with the sodium salts of ethyl cyanoacetate and malononitrile gave 2-substituted thiazole (16), 3-(2-mercaptoethyl)-thiazoline (17) and/or its disulfide (18). The tautomeric forms of 2,12 and 16 are discussed on the basis of the structures of the methylated products and of their spectrophotometric properties.
- 公益社団法人日本薬学会の論文
- 1975-12-25
著者
-
宮坂 貞
School of Pharmaceutical Sciences, Showa University
-
宮坂 貞
School Of Pharmaceutical Sciences Showa University
-
荒川 基一
School of Pharmaceutical Sciences, Showa University
-
大塚 宏子
School Of Pharmaceutical Sciences Showa University
-
荒川 基一
School Of Pharmaceutical Sciences Showa University
関連論文
- Synthesis of 5-Carbon-Substituted 1-β-D-Ribofuranosylimidazole-4-carboxamides via Lithiation of a Primary Carboxamide(Organic,Chemical)
- REACTION OF ORGANOMETALLIC REAGENTS WITH 2'- AND 3'-KETOURIDINE DERIVATIVES : SYNTHESIS OF URACIL NUCLEOSIDES BRANCHED AT THE 2'- AND 3'-POSITIONS(Communications to the Editor)
- Chemical Modification of Antitumor Alkaloids, 20(S)-Camptothecin and 7-Ethylcamptothecin : Reaction of the E-Lactone Ring Portion with Hydrazine Hydrate
- Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives : Carbamate-Linked, Water-Soluble Derivaties of 7-Ethyl-10-hydroxycamptothecin
- Diethylaminosulfur Trilfluoride (DAST) as a Fluorinating Agent of Pyrimidine Nucleosides Having a 2', 3'-Vicinal Diol System
- Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives. A-Ring-Substituted 7-Ethylcamptothecins and Their E-Ring-Modified Water-Soluble Derivatives
- Synthesis and Antiumor Activity of 20(S)-Camptothecin Derivatives : A-Ring Modified and 7,10-Disubstituted Camptothecins
- Synthesis and Optical Properties of 2'-Deoxy-8,2'-methanoguanosine
- REACTION OF URACIL NUCLEOSIDES WITH 1-METHYLIMIDAZOLE IN THE PRESENCE OF PHOSPHORYL CHLORIDE : A CONVENIENT METHOD FOR THE SYNTHESIS OF 4-SUBSTITUTED PYRIMIDIN-2 (1H)-ONE NUCLEOSIDES
- PALLADIUM-CATALYZED CROSS-COUPLING OF 2-IODOADENOSINE WITH TERMINAL ALKYNES : SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 2-ALKYNYLADENOSINES
- CONVERSION OF GUANOSINE INTO 2-AMINOMETHYLINOSINE (2-HOMOGUANOSINE)
- SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 5-SUBSTITUTED 6-PHENYLTHIO AND 6-IODOURIDINES, A NEW CLASS OF ANTILEUKEMIC NUCLEOSIDES
- The Reaction of 6-Phenylthiouridine with Sulfur Nucleophiles : A Simple and Regiospecific Preparation of 6-Alkylthiouridines and 6-Alkylthiouridylic Acids
- A SIMPLIFIED SYNTHESIS OF 8-SUBSTITUTED PURINE NUCLEOSIDES VIA LITHIATION OF 6-CHLORO-9-(2,3-O-ISOPROPYLIDENE-β-D-RIBOFURANOSYL) PURINE
- Chemical Modification of an Antitumor Alkaloid, 20(S)-Camptothecin : E-Lactone Ring-Modified Water-Soluble Derivatives of 7-Ethylcamptothecin
- Chemical Modification of an Antitumor Alkaloid, 20(S)-Camptothecin : Glycosides, Phosphates and Sulfates of 7-Ethyl 10-hydroxycamptothecin
- Chemical Modification of an Antitumor Alkaloid Camprothecin : Synthesis and Antitumor Activity of 7-C-Substituted Camptothecins
- Studies of Heterocyclic Compounds. XVIII. Synthesis of 1-(Substitutedphenyl)-2,3-tetramethylenepyrrolo [2,1-b] benzothiazoles
- Studies of Heterocyclic Compounds. XVII. Synthesis of 3-(Substituted-phenyl)-thiazolo [2,3-b] benzothiazolium Perchlorates
- Introduction of an Alkyl Group into the Sugar Portion of Uracilnucleosides by the Use of Gilman Reagents
- Direct C-8 Lithiation of Naturally-Occurring Purine Nucleosides. A Simple Method for the Synthesis of 8-Carbon-Substituted Purine Nucleosides(Organic,Chemical)
- Studies on Heterocyclic Compounds. XXII. The Reaction of Oxazolo [3,2-b] pyridazinium Perchlorates with Hydroxylamines
- 複素環化合物の研究(第21報)Thiazolo[3,2-b]pyridazinium Perchlorateとヒドラジン類との反応
- Synthesis of 2-Substituted 2,6-Dihydro-3-hydroxy-7H-pyrazolo [4,3-d] pyrimidin-7-ones
- A NOVEL AND REGIOSPECIFIC ROUTE TO 5-ACYLURIDINES VIA AN AMIDE α-ANION DERIVED FROM 5,6-DIHYDROURIDINE
- FIRST EXCEPTIONS TO THE"IMBACH RULE"FOR β-D-RIBOFURANOSYL NUCLEOSIDES
- Studies on Heterocyclic Compounds. XX. The Reaction of the Oxazolo [3,2-b] pyridazinium Perchlorates with Hydrazines
- Studies on Heterocyclic Compounds. XIX. The Reaction of the Thiazolo [3,2-b] pyridazinium Perchlorates with Carbanions
- 複素環化合物の研究(第11報)Oxazolo[3,2-b]pyridazinium Perchlorateの合成と炭素求核試薬との反応
- Studies of Heterocyclic Compounds. X. The Reaction of the Thiazolo [3,2-b] pyridazinium Perchlorates with Potassium Cyanide
- Studies of Heterocyclic Compounds. IX. The Synthesis and the Properties of Thiazolo [3,2-b] pyridazin-4-ium Perchlorates
- SYNTHESIS OF NEW FLUORESCENT NUCLEOSIDES, 3-β-D-RIBOFURANOSYLPYRAZOLO [3,2-i__-] PURINE DERIVATIVES AND THEIR CYTOTOXIC ACTIVITIES
- Synthesis of 6-C-Substituted Purine Nucleosides : α-(Aminomethylene)-9-β-D-ribofuranosylpurine-6-acetic Acid Derivatives
- Substituent and Solvent Effects on the Tautomeric Equilibria of N-Substituted α-(Aminomethylene)purine-6-acetonitrile Derivatives
- Synthesis of 6-C-Substituted 9-Tetrahydrofuranylpurine Derivatives
- Interrelation of Methyl Sciadopate with Communic Acid and Daniellic Acid
- Studies of Heterocyclic Compounds. VII. The Reactions of 5,6-Dihydrothiazolo [2,3-b] thiazolium Salts with Carbanions
- Studies of Heterocyclic Compounds. VI. The Reactions of 5,6-Dihydrothiazolo [2,3-b] thiazolium Salts with O-and S-Nucleophiles
- Studies of Heterocyclic Compounds. V. Synthesis of 5,6-Dihydrothiazolo-[2,3-b] thiazolium Salts and Their Reactions with Amines. A New Synthesis of 2-Aminothiazoles
- Synthesis of N-Free 4-Hydroxy-2-thiazoline as an Intermediate in the Hantzsch Thiazole Synthesis
- The Synthesis of 3-Phenyl-4-(β-and-α-D-ribofuranosyl) pyrazole and the Configuration of C-Ribosylethynyl Derivatives
- 複素環化合物の研究(第14報)1-(2-Haloethyl)pyrazole類の脱ハロゲン化水素化反応による1-Vinylpyrazole類の合成
- N-Phenylmaleimideに対するAryldiazomethaneの付加による3-置換Pyrrolo[3,4-c]pyrazole-4,6(1H, 5H)-dione誘導体の合成
- Synthesis of 6-Aroyluridine from Uridine via Regiospecific Lithiation
- Studies of Heterocyclic Compounds. II. Acetyl Transfer Reactions of 3-Acetoxy-1-acetyl-5-methylpyrazole and the Related Compounds
- Studies of Heterocyclic Compounds. I. Structures of Acetylated Products of 3-Methylpyrazol-5-one