SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 5-SUBSTITUTED 6-PHENYLTHIO AND 6-IODOURIDINES, A NEW CLASS OF ANTILEUKEMIC NUCLEOSIDES
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概要
- 論文の詳細を見る
A new class of 5,6-disubstituted uridines, in which the C-6 position was occupied by phenylthio group or iodine, were synthesized via lithiation of the corresponding 5-substituted 2', 3'-O-isopropylidene-5'-O-methoxymethyluridines and subsequent electrophilic reactions. These newly-synthesized uridine derivatives exhibited antileukemic activities against mouse leukemia L5178Y cells in culture.
- 公益社団法人日本薬学会の論文
- 1983-06-25
著者
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田中 博道
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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松田 彰
Faculty Of Pharmaceutical Sciences Hokkaido University
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宮坂 貞
昭和大学大学院薬学研究科医療薬学専攻
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早川 弘之
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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松田 彰
School of Pharmaceutical Sciences, Showa University
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飯島 秀治
School of Pharmaceutical Sciences, Showa University
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