複素環化合物の研究(第21報)Thiazolo[3,2-b]pyridazinium Perchlorateとヒドラジン類との反応
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概要
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Treatment of thiazolo[3,2-b]pyridazinium perchlorates (I) with hydrazine hydrate afforded 1,4-bis (2-vinyl-2,3-dihydro-3-pyridazinylidene)-2-tetrazenes (II), 1-(1,6-dihydro-6-thioxopyridazin) ylacetaldehyde azines (III), 2-alkylpyridazine-3-thiones (IV), 3,4-dihydro-2H-pyridazino[6,1-c] [1,2,4]triazines (V), s-triazolo[4,3-b]pyridazines (VI, VI'), pyridazino[6,1-c] [1,2,4]triazinium salts (VII), imidazo[1,2-b]pyridazines (VIII), 8-aminothiazolo[3,2-b]pyridazinium salts (IX) and pyridazine-3-thiones (X), depending upon the substituents of the substrates, reaction time and temperature. Catalytic reduction of the tetrazenes (II) gave V and oxidation with 30% H_2O_2 in acetic acid yielded 3,4-dihydro-2H-pyridazino[6,1-c] [1,2,4]triazin-3-ones (XV).
- 公益社団法人日本薬学会の論文
- 1983-04-25
著者
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佐藤 和恵
School Of Pharmaceutical Sciences Showa University
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佐藤 和恵
昭和大学薬学部分析センター
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佐藤 和恵
昭和大学院薬
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宮坂 貞
昭和大学大学院薬学研究科医療薬学専攻
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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