Synthesis of 6-C-Substituted Purine Nucleosides : α-(Aminomethylene)-9-β-D-ribofuranosylpurine-6-acetic Acid Derivatives
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概要
- 論文の詳細を見る
α-(Aminomethylene)-β-D-ribofuranosylpurine-6-acetamide (4) and the ethyl acetate (9) have been synthesized by catalytic hydrogenation of 6-cyanomethylenepurine derivatives (3 and 7). 6-Cyanomethylenepurines were obtained by substitution of 6-chloro-9-(2,3-O-isopropylidene-β-D-ribofuranosyl)purine (1) with α-cyanoacetamide and ethyl cyanoacetate, followed by deprotection of the isopropylidene group. Substitution on 4 and 9 with benzylamine and aniline gave the corresponding N-benzyl- and N-phenyl-substituted α-(aminomethylene)-β-D-ribofuranosylpurine-6-acetamides (5) and the ethyl acetate (10), respectively.
- 公益社団法人日本薬学会の論文
- 1992-04-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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浜道 則光
School Of Pharmaceutical Sciences Showa University
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