CONVERSION OF GUANOSINE INTO 2-AMINOMETHYLINOSINE (2-HOMOGUANOSINE)
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概要
- 論文の詳細を見る
2-Aminomethylinosine (1), a one-carbon extended homolog of an exocyclic amino group of guanosine, was synthesized from guanosine by the use of a newly developed protection and deprotection method. Introduction of a methoxy group into the 6-position of 2-benzenesulfonyl-purine riboside facilitated a nucleophilic substitution with cyanide to afford 2-cyano-6-methoxypurine riboside (11) which was subsequently hydrogenated and demethylated with trimethylsilyl iodide to afford 1.
- 公益社団法人日本薬学会の論文
- 1984-05-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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佐藤 和恵
School Of Pharmaceutical Sciences Showa University
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佐藤 和恵
昭和大学薬学部分析センター
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佐藤 和恵
昭和大学院薬
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松田 彰
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
Faculty Of Pharmaceutical Sciences Hokkaido University
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宮坂 貞
昭和大学大学院薬学研究科医療薬学専攻
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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上田 亨
北海道大学薬学部
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松田 彰
School of Pharmaceutical Sciences, Showa University
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上田 亨
Fuculty of Pharmaceutical Sciences, Hokkaido University
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