Synthesis and Antitumor Activity of 20(S)-Camptothecin Derivatives : Carbamate-Linked, Water-Soluble Derivaties of 7-Ethyl-10-hydroxycamptothecin
スポンサーリンク
概要
- 論文の詳細を見る
Nevel 36 derivatives (6), bonding the phenolic hydroxyl group of 7-ethyl-10-hydroxycamptothecin (4) with diamines through a monocarbamate linkage, were synthesized and their antitumor activity was evaluated in vivo. The derivatives were soluble in water as their HC1 salts wiht the E lactone ring intact and exhibited significant antitumor activity. One of the derivatives, 6-27 showed excellent activity against L1210 leukemia and other murine tumors.The structure of its hydrochloride trihydrate (CPT-11) was determined by spectroscopic and crystallographic methods.
- 社団法人日本薬学会の論文
- 1991-06-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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澤田 誠吾
Yakult Central Institute of Microbiological Research
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山口 健太郎
School of Pharmaceutical Sciences, Showa University
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杉野 栄一
福山大学
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澤田 誠吾
ヤクルト本社中央研究所
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杉野 栄一
Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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山口 健太郎
School Of Pharmaceutical Sciences Showa University
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岡島 悟
School Of Pharmacy Hokuriku University
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岡島 悟
ヤクルト本社中央研究所
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横倉 輝男
ヤクルト中央研究所
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相山 律男
ヤクルト中央研究所
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相山 律男
Yakult Central Institute For Microbiological Research
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沢田 誠吾
Yakult Central Institute for Microbiological Research
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古田 富雄
Yakult Central Institute for Microbiological Research
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岡島 悟
Yakult Institute for Microbiological Research
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野方 健一郎
Yakult Institute for Microbiological Research
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横倉 輝雄
Yakult Institute for Microbiological Research
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Sawada S
Yakult Central Institute Of Microbiological Research
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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野方 健一郎
Yakult Central Institute For Microbiological Research
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