ANTITUMOR ACTIVITY OF A NEW CAMPTOTHECIN DERIVATIVE, SN-22,AGAINST VARIOUS MURINE TUMORS
スポンサーリンク
概要
- 論文の詳細を見る
The antitumor activity of a new camptothecin derivative, SN-22,was evaluated by using various murine tumors. SN-22 showed strong activity against the ascites tumors Ehrlich carcinoma, MM46,CCM, L1210,L5178Y, P388,Meth A, and B16 melanoma. In particular, the maximum increase in life span values for Ehrlich, MM46 and CCM were as high as 253-606% and many mice were cured of these tumors. The effect of SN-22 against solid tumors was also determined. The inhibition ratios were higher than 70% for MM46 and L5178Y. The LD_<50> of SN-22 in ICR mice was about 1.5 times that of the parent camptothecin.
- 公益社団法人日本薬学会の論文
著者
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澤田 誠吾
Yakult Central Institute of Microbiological Research
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澤田 誠吾
ヤクルト本社中央研究所
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Uehara N
National Cancer Center Research Inst. Tokyo Jpn
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Uehara Nobuaki
Chemotherapy
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Sawada Seigo
Chemotherapy Division National Cancer Center Research Institute:pharmacology Division National Cance
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Nitta Kazuo
Chemotherapy Division Chiba Cancer Center Research Institute:chemotherapy Division National Cancer C
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Yokokura Teruo
Chemotherapy Division National Cancer Center Research Institute:pharmacology Division National Cance
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KUNIMOTO TAKEHIKO
Chemotherapy Division National Cancer Center Research Institute
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TANAKA TOMIKO
Chemotherapy Division National Cancer Center Research Institute
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BABA HIROYASU
Chemotherapy Division National Cancer Center Research Institute
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TAKEUCHI MIEKO
Chemotherapy Division National Cancer Center Research Institute
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MIYASAKA TADASHI
Chemotherapy Division National Cancer Center Research Institute
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MUTAI MASAHIKO
Chemotherapy Division National Cancer Center Research Institute
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Tanaka Tomiko
Chemotherapy Division National Cancer Center Research Institute:pharmacology Division National Cance
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Baba Hiroyasu
Chemotherapy Division Chiba Cancer Center Research Institute:chemotherapy Division National Cancer C
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Mutai Masahiko
Chemotherapy Division National Cancer Center Research Institute:pharmacology Division National Cance
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Miyasaka Tadashi
Chemotherapy Division National Cancer Center Research Institute:pharmacology Division National Cance
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Kunimoto Takehiko
Chemotherapy Division Chiba Cancer Center Research Institute:chemotherapy Division National Cancer C
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Takeuchi Mieko
Chemotherapy Division National Cancer Center Research Institute:pharmacology Division National Cance
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