Studies of Heterocyclic Compounds. V. Synthesis of 5,6-Dihydrothiazolo-[2,3-b] thiazolium Salts and Their Reactions with Amines. A New Synthesis of 2-Aminothiazoles
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概要
- 論文の詳細を見る
5,6-Dihydrothiazolo [2,3-b] thiazolium salts (1a-d) were synthesized from 2-mercapto-thiazoline and α-haloketones. The reaction of 1 with a secondary amine gave 2-aminothiazole (7a-1) with the liberation of thiirane (9) via an unstable adduct, 7a-amino-2,3,5,6-tetrahydrothiazolo [2,3-b] thiazole (8a-g). The reaction of 1 with a primary amine afforded 3-(2-mercaptoethyl)-4-thiazolin-2-imine (10) and/or its disulfide (11). The reaction of 1 with an amine was concluded to be initiated by the attack of the reagent on C-7a.
- 公益社団法人日本薬学会の論文
- 1975-12-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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荒川 基一
School of Pharmaceutical Sciences, Showa University
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大塚 宏子
School Of Pharmaceutical Sciences Showa University
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豊稲 初則
School of Pharmaceutical Sciences, Showa University
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荒川 基一
School Of Pharmaceutical Sciences Showa University
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豊稲 初則
School Of Pharmaceutical Sciences Showa University
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