Synthesis of 6-C-Substituted 9-Tetrahydrofuranylpurine Derivatives
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概要
- 論文の詳細を見る
6-Dicyanomethylene-9-tetrahydrofuranylpurine (4), which was obtained by the reaction of 9H-1,6-dihydropurine-Δ^<6,α>-propanedinitrile (3) with 2,3-dihydrofuran, has been catalytically hydrogenated to the α-(aminomethylene)-9-(tetrahydrofuran-2-yl)-9H-purine-6-acetonitrile (5) in good yield using N, N-dimethylformamide-benzene as a solvent over Pd-C under medium pressure. Substitution of 5 with amines gave the corresponding alkylaminomethylene purines (6 and 7). Reaction of 5 with hydrazine gave the pyrazole derivative (8).
- 公益社団法人日本薬学会の論文
- 1990-07-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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浜道 則光
School Of Pharmaceutical Sciences Showa University
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