Studies of Heterocyclic Compounds. II. Acetyl Transfer Reactions of 3-Acetoxy-1-acetyl-5-methylpyrazole and the Related Compounds
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概要
- 論文の詳細を見る
The individual reactions of acetyl group rearrangement are examined to elucidate the complicated formation of five acetylated products of 3-methylpyrazol-5-one (I). In heated acetic acid-anhydride mixture the initially formed 2-acetyl-3-hydroxy-5-methylpyrazole (II) reacts further to produce 1-acetyl-3-hydroxy-5-methylpyrazole (III), 3-acetoxy-2-acetyl-5-methylpyrazole (IV) and finally 3-acetoxy-1-acetyl-5-methylpyrazole (V), while inter- as well as intra-molecular acetyl transfer reaction takes place. The diacetate (V) is a sort of activated ester and is proved to be effective as a mild acetylating reagent of primary and secondary amines.
- 公益社団法人日本薬学会の論文
- 1974-01-25
著者
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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荒川 基一
School of Pharmaceutical Sciences, Showa University
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越智 久雄
昭和大学薬学部
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越智 久雄
School Of Pharmaceutical Sciences Showa University
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荒川 基一
School Of Pharmaceutical Sciences Showa University
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