複素環化合物の研究(第14報)1-(2-Haloethyl)pyrazole類の脱ハロゲン化水素化反応による1-Vinylpyrazole類の合成
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概要
- 論文の詳細を見る
Heating of 3,5-disubstituted 1-(2-hydroxyethyl) pyrazoles with 47% hydrogen bromide afforded 3,5-disubstituted 1-(2-bromoethyl) pyrazoles. 3,5-Dimethyl-, 3,5-diphenyl-, 5-chloro-3-methyl-and 5-chloro-3-phenyl-1-vinylpyrazoles were synthesized by dehydrohalogenation of the corresponding 1-(2-haloethyl) pyrazoles with potassium hydroxide in ethanol. However, treatment of 1-(2-bromoethyl)-5-hydroxy-3-methyl-and-3-phenylpyrazoles under the same reaction condition afforded cyclized products ; 2,3-dihydro-6-methyl- and-6-phenylpyrazolo [3,2-b] oxazoles, respectively. Treatment of 5-benzoyloxy-1-(2-bromoethyl)-3-methyl-and-3-phenylpyrazoles with sodium t-butoxide in butanol furnished 5-hydroxy-3-methyl-and-3-phenyl-1-vinylpyrazoles.
- 公益社団法人日本薬学会の論文
- 1978-02-25
著者
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宮坂 貞
昭和大学薬学部
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荒川 基一
School of Pharmaceutical Sciences, Showa University
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荒川 基一
昭和大学薬学部
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越智 久雄
昭和大学薬学部
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荒川 基一
School Of Pharmaceutical Sciences Showa University
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