SYNTHESIS OF NEW FLUORESCENT NUCLEOSIDES, 3-β-D-RIBOFURANOSYLPYRAZOLO [3,2-i__-] PURINE DERIVATIVES AND THEIR CYTOTOXIC ACTIVITIES
スポンサーリンク
概要
- 論文の詳細を見る
The novel nucleosides 3-β-D-ribofuranosylpyrazolo [3,2-i__-]purine (8) and their 9-substituted bromo, nitro and amino compounds (3,6,and 11) have been prepared from a fully protected 3-β-D-ribofuranosyl [3,2-i__-]purine-9-carboxyamide 1 by dromodeamidation (ipso bromination). Compounds 3,8 and 11 exhibited antileukemic activity against mouse leukemia L5178Y cells in culture, while the 9-substituted nitro, ester and amide compounds (6,12 and 13) showed no cytotoxity.
- 公益社団法人日本薬学会の論文
- 1992-09-25
著者
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宮坂 貞
School of Pharmaceutical Sciences, Showa University
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宮坂 貞
School Of Pharmaceutical Sciences Showa University
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浜道 則光
School Of Pharmaceutical Sciences Showa University
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浜道 則光
(present address) Department of Chemistry, University of Virginia
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