The Degradation Pathway of 1,2,3,4-Tetrazine

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概要

• 論文の詳細を見る

• The potential energy surfaces of the degradations of 1,2,3,4-tetrazine (1a) to C_2H_2+2N_2 or 2HCN+N_2 were obtained from semiempirical molecular orbital calculations using the AM1 method. It was suggested that the degradation of 1a to 2HCN+N_2 occurred in a concerted fachion, whereas the decomposition to C_2H_2+2N_2 was demonstrated to proceed via a stepwise pathway. The latter process was more favorable than the former, and was analogous to the degradation process of 2-phenyl-2H-[1,2,3]triazolo[4,5-e][1,2,3,4]tetrazine (3), which is the only example of 1,2,3,4-tetrazine ring.

• 社団法人日本薬学会の論文
• 1990-12-25

著者

• 山口 健太郎

  School of Pharmaceutical Sciences, Showa University

• 大沢 昭緒

  School of Pharmaceutical Sciences, Showa University

• 山口 健太郎

  School Of Pharmaceutical Sciences Showa University

• 海宝 輝光

  School of Pharmaceutical Sciences, Showa University

• 伊藤 喬

  昭和大学薬学部薬化学教室

• 伊藤 喬

  School of Pharmaceutical Sciences, Showa University

• 大沢 昭緒

  School Of Pharmaceutical Sciences Showa University

• 海宝 輝光

  School Of Pharmaceutical Sciences Showa University

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