放射化分析法によるセレン欠乏ラット及びビタミンE欠乏ラット臓器中元素含量の測定

概要

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The contents of iron (Fe), cobalt (Co), zinc (Zn), and selenium (Se) in the organs (liver, kidney, spleen, heart, lung, and brain) and the liver cell fractions (nuclear, mitochondrial, microsomal, and cytosolic fractions) of Se- or vitamin E (VE) -deficient rats were measured using instrumental neutron activation analysis (INAA). The contents of Fe in the liver of Se-deficient rats, and in the liver and the spleen of VE-deficient rats were increased compared with those in normal rats. Fe contents increased mainly in the microsomal fraction. Contents of Co in the organs and liver cell fractions of Se- and VE-deficient rats were markedly low, reflecting the Co contents in both diets. Contents of Zn in the organs and liver cell fractions of Se- and VE-deficient rats decreased to 6O-8O% of the contents in normal rats. The Se contents in Se-deficient rat organs except for the kidney, spleen, and brain were below the detectable level under the present conditions. Se contents in VE-deficient rat decreased to 5O-8O% of those in normal rats in all organs and fractions. It is suggested that oxidative stress due to Se- or VE-deficiency affects the dynamics of Fe and Zn.
公益社団法人日本薬学会の論文
2002-04-01