Nucleosides and Nucleotides. LIV. Synthesis of 6,6'-Cyclo-5', 6'-dideoxyhexofuranosyluracils via Radical Cyclization of a 6-Cyanouridine
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概要
- 論文の詳細を見る
Synthesis of hexofuranosyluracil cyclonucleosides carbon-bridged between C-6 and C-6'is described. Treatment of 6-cyano-5'-iodo-2', 3'-O-isopropylidene-5'-deoxyuridine with tri-n-butyltin hydride and 2,2'-azobisisobutyronitrile gave the 6'-imino-6,6'-cyclo-5', 6'-dideoxyallofuranosyluracil, which was converted to the 6'-oxo derivative. The 6'-oxo function was reduced with sodium borohydride and the 6'-hydroxyl group was eliminated to give the 5', 6'-unsaturated cyclodideoxyallofuranosyluracil, which was hydrogenated to furnish 6,6'-cyclo-5', 6'-dideoxyallofuranosyluracil, a uridine derivative fixed in the anti form.
- 社団法人日本薬学会の論文
- 1985-05-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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上田 亨
Faculty Of Pharmaceutical Sciences Hokkaido University
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佐野 友春
Faculty of Pharmaceutical Sciences, Hokkaido University
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井上 英夫
Faculty of Pharmaceutical Sciences, Hokkaido University
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井上 英夫
北海道大学薬学部
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佐野 友春
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
北海道大学薬学部
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井上 英夫
Faculty Of Pharmaceutical Sciences Hokkaido University
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