A FACILE SYNTHESIS OF 6,3'-METHANO-URIDINE AND-CYTIDINE FROM A 3-KETOSUGAR : NUCLEOSIDES AND NUCLEOTIDES LXVIII
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概要
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The synthesis of 6,3'-methanouridine was achieved by condensation of 2,4-dimethoxy-6-lithiomethylpyrimidine with 5-O___--(tert-butyldi-methyl)silyl-1,2-O___--isopropylidene-3-ketoxylose, followed by intramolecular glycosylation and deprotection. 6,3'-Methanocytidine was also prepared from the 4-O___--methyl intermediate. The title compounds are the first example of uridine and cytidine fixed between C-6 and the 3'-position of pyrimidine nucleosides by a methylene group.
- 公益社団法人日本薬学会の論文
- 1986-01-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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上田 亨
Faculty Of Pharmaceutical Sciences Hokkaido University
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佐野 友春
Faculty of Pharmaceutical Sciences, Hokkaido University
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佐野 友春
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
北海道大学薬学部
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