Nucleosides and Nucleotides. V. Identification and Substitution Reaction of 1-Methyl-2,4-dialkoxypyrimidinium Salts : Model Studies on Hilbert-Johnson Pyrimidine Nucleoside Synthesis
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概要
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Methylation of 2,4-dialkoxypyrimidines with methyl iodide gave the reactive 1-methyl-pyrimidinium salts, the intermediates to 1-methyl-4-alkoxy-2-pyrimidinones. The isolation of the 1-methylpyrimidinium salt verifies the postulated mechanism of the Hilbert-Johnson reaction for pyrimidine nucleoside synthesis. The results of the substitution reaction of various 2,4-disubstituted 1-methylpyrimidinium salts are described and the device of the extension of the Hilbert-Johnson procedure for the general method of the synthesis of 2-substituted pyrimidine nucleosides is discussed.
- 公益社団法人日本薬学会の論文
- 1973-07-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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大塚(西野) 宏子
Faculty Of Pharmaceutical Sciences Hokkaido University
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