Synthesis of 6,6'-Cyclo-5', 6'-dideoxy-1-(β-D-allofuranosyl)cytosine and Related Nucleosides : Nucleosides and Nucleotides.LXXXVIII)
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概要
- 論文の詳細を見る
A new synthetic route to 6,6'-cyclo-5', 6'-dideoxy-1-(β-D-allofuranosyl)-uracil, -cytosine, and -4-thiouracil is described. The method involves a base-catalyzed condensation of 2,4-dimethoxy-6-methylpyrimidine and 1-O-methyl-2,3-O-isopropylidene-β-D-ribopentofuranosyldialdehyde, followed by an intramolecular glycosylation, and derivatization of the base moiety. The relationship of the sign of the circular dichroism (CD) spectra of carbon-bridged cyclopyrimidine nucleosides to the glycosyl torsion angle is discussed.
- 社団法人日本薬学会の論文
- 1989-03-25
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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松田 彰
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
Faculty Of Pharmaceutical Sciences Hokkaido University
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吉村 祐一
Faculty Of Pharmaceutical Sciences Hokkaido University
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上田 亨
北海道大学薬学部
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