Chemical Synthesis of Guanosine Diphosphate Mannose (GDPM)
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概要
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Guanosine diphosphate mannose (GDPM), coenzyme of mannose polymerization, was chemically synthesized. GMP and cyclohexylamine were condensed to form N-cyclohexylphosphoramidate in the presence of DCC. The amidate (III) was reacted with benzyl hydrogen phosphate and after hydrogenation led to GDP (V). (III) and α-d-mannos-1-yl phosphate were condensed in pyridine and, after isolation and purification by ion-exchange chromatography, 83.5% pure GDPM was obtained in 32% yield. The synthetic GDPM was quite identical with the natural one in all respects.
- 公益社団法人日本薬学会の論文
- 1959-12-20
著者
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上田 亨
Faculty of Pharmaceutical Science, Hokkaido University
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大塚 英子
Faculty Of Pharmacy School Of Medicine Hokkaido University
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